Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates
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چکیده
منابع مشابه
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase.
The medicinal properties of marijuana have been recognized for centuries, but clinical and societal acceptance of this drug of abuse as a potential therapeutic agent remains fiercely debated. An attractive alternative to marijuana-based therapeutics would be to target the molecular pathways that mediate the effects of this drug. To date, these neural signaling pathways have been shown to compri...
متن کاملCharacterization of the fatty-acid amide hydrolase inhibitor URB597: Effects on anandamide and oleoylethanolamide deactivation
Memory, University of California, Irvine, California 92697-4625 (D.F., S.G., D.P.), Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Urbino “Carlo Bo”,Piazza del Rinascimento 6, I-61029 Urbino, Italy (A.D., A.T., G.T.) and Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43100 Parma, Italy (M.M.) JPET Fast Forward. Published...
متن کاملRole of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.
A facilitated transport process that removes the endogenous cannabinoid anandamide from extracellular spaces has been identified. Once transported into the cytoplasm, fatty acid amide hydrolase (FAAH) is responsible for metabolizing the accumulated anandamide. We propose that FAAH contributes to anandamide uptake by creating and maintaining an inward concentration gradient for anandamide. To ex...
متن کاملIncreased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
A number of recent in vitro studies have described a role for endogenous cannabinoids ("endocannabinoids") as transsynaptic modulators of neuronal activity in the hippocampus and other brain regions. However, the impact that endocannabinoid signals may have on activity-dependent neural events in vivo remains mostly unknown and technically challenging to address because of the short half-life of...
متن کاملFatty acid amide hydrolase determines anandamide-induced cell death in the liver.
The endocannabinoid anandamide (AEA) induces cell death in many cell types, but determinants of AEA-induced cell death remain unknown. In this study, we investigated the role of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) in AEA-induced cell death in the liver. Primary hepatocytes expressed high levels of FAAH and were completely resistant to AEA-induced cell death, whereas prima...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2008
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2008.08.008